What 550 5.7.510 means
Microsoft documents 5.7.510 as 'Access denied, [domain] does not accept email over IPv6'. Your server connected to Microsoft 365 over IPv6, but the recipient organization hasn't enabled inbound IPv6, so the message was refused.
Nothing is wrong with the address or with your reputation. It's a transport mismatch that only affects self-managed servers that prefer IPv6.
What the bounce looks like
The wording providers document for this code. Your bounce may add an IP address, a session ID or a help link after it.
550 5.7.510 Access denied, [domain] does not accept email over IPv6 Why cold emailers see 550 5.7.510
- A self-hosted MTA (Postfix, Exim) with IPv6 enabled that prefers IPv6 when the MX has an AAAA record.
- An SMTP provider routing some traffic over IPv6.
- A new cloud server where IPv6 is on by default, so the MTA starts using it without anyone choosing to.
How to fix 550 5.7.510
- Configure your MTA to deliver over IPv4 for these destinations, or entirely (in Postfix, smtp_address_preference = ipv4 or inet_protocols = ipv4).
- If you need IPv6, make sure your sending IPv6 address has reverse DNS and passes SPF or DKIM, which Microsoft requires for IPv6 senders anyway.
- Resend after the change.
Retry or suppress?
Don't suppress. Switch delivery to IPv4 and resend.
Reading the code
The basic code 550 means "Mailbox unavailable or message refused (permanent)" under RFC 5321. In 5.7.510, the 5 is the class (permanent failure) and the 7 is the subject (security or policy). The detail number 510 isn't in the RFC 3463 / IANA registry; it's specific to the provider, so the text after the code carries the meaning.
- Class 5
- Permanent failure
- Resending the same message won't work. Something about the message, the recipient or the sender has to change first.
- Subject 7
- Security or policy
- A security or policy decision: spam filtering, authentication, blocklists, permissions.
- Detail 5.7.510
- Provider-specific
Check the rest of your setup
Paste the headers of a message that did get through into the email header analyzer to confirm SPF, DKIM and DMARC pass, and check your domain with the SPF, DKIM & DMARC checker. The deliverability checklist covers the rest of a healthy sending setup.
Got a different bounce? Paste it into the SMTP error code lookup to decode it.